location: Jefferson National Forrest near Arcadia, VA
There are multiple ways you can do this loop including getting all the way up to the AT rather than taking the fire road connector and multiple trailheads to start at. My preferred trailhead is the trailhead at FS59 as described by hiking upwards in the link above. That way you do the climbing first before the downhills.
On the loop, there are many stinging nettles, especially on the Cornelius Creek Trail and the fire road. So it is recommend to cover your legs in the summer.